diff --git a/BUILD.md b/BUILD.md
index a23ea66a..458ffba1 100644
--- a/BUILD.md
+++ b/BUILD.md
@@ -250,6 +250,7 @@ Example usage: `cmake -S . -B build -DCMAKE_BUILD_TYPE=release -DENABLE_SDL=ON -
 | ENABLE_VCPKG       |   | Use VCPKG package manager to obtain dependencies                            | ON      |                    |
 | ENABLE_VULKAN      |   | Enable the Vulkan graphics backend                                          | ON      |                    |
 | ENABLE_WXWIDGETS   |   | Enable wxWidgets UI                                                         | ON      | Currently required |
+| ENABLE_LIBUSB      |   | Enable libusb                                                               | ON      |                    |
 
 ### Windows
 | Flag               | Description                       | Default | Note               |
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 7b1e86d5..f04ab816 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -132,6 +132,13 @@ endif()
 
 option(ENABLE_HIDAPI "Build with HIDAPI" ON)
 option(ENABLE_SDL "Enables the SDLController backend" ON)
+option(ENABLE_LIBUSB "Build with libusb support" ON)
+
+if (ENABLE_LIBUSB)
+	add_compile_definitions(HAS_LIBUSB)
+else()
+	add_compile_definitions(HAS_LIBUSB)
+endif()
 
 # audio backends
 if (WIN32)
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 291cc612..b266a6c6 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -119,10 +119,12 @@ if (MACOS_BUNDLE)
 			COMMAND ${CMAKE_COMMAND} ARGS -E copy_directory "${CMAKE_SOURCE_DIR}/bin/${folder}" "$<TARGET_BUNDLE_DIR:CemuBin>/Contents/SharedSupport/${folder}")
 	endforeach(folder)
 
-	if(CMAKE_BUILD_TYPE STREQUAL "Debug")
-	    set(LIBUSB_PATH "${CMAKE_BINARY_DIR}/vcpkg_installed/${VCPKG_TARGET_TRIPLET}/debug/lib/libusb-1.0.0.dylib")
-	else()
-	    set(LIBUSB_PATH "${CMAKE_BINARY_DIR}/vcpkg_installed/${VCPKG_TARGET_TRIPLET}/lib/libusb-1.0.0.dylib")
+	if (ENABLE_LIBUSB)
+		if(CMAKE_BUILD_TYPE STREQUAL "Debug")
+		    set(LIBUSB_PATH "${CMAKE_BINARY_DIR}/vcpkg_installed/${VCPKG_TARGET_TRIPLET}/debug/lib/libusb-1.0.0.dylib")
+		else()
+		    set(LIBUSB_PATH "${CMAKE_BINARY_DIR}/vcpkg_installed/${VCPKG_TARGET_TRIPLET}/lib/libusb-1.0.0.dylib")
+		endif()
 	endif()
 
 	if (EXISTS "/usr/local/lib/libMoltenVK.dylib")
@@ -142,9 +144,11 @@ if (MACOS_BUNDLE)
 		COMMAND ${CMAKE_COMMAND} -E copy 
 			"${MOLTENVK_PATH}"
 			"${FRAMEWORKS_DIR}/libMoltenVK.dylib"
-		COMMAND ${CMAKE_COMMAND} -E copy
-			"${LIBUSB_PATH}"
-			"${FRAMEWORKS_DIR}/libusb-1.0.0.dylib"
+    if (ENABLE_LIBUSB)
+      COMMAND ${CMAKE_COMMAND} -E copy
+        "${LIBUSB_PATH}"
+        "${FRAMEWORKS_DIR}/libusb-1.0.0.dylib"
+    endif()
 		COMMAND ${CMAKE_COMMAND} -E copy
 			"${UPDATE_SH_PATH}"
 			"${RESOURCES_DIR}/update.sh"
@@ -157,12 +161,14 @@ if (MACOS_BUNDLE)
 		INSTALL_RPATH "@executable_path/../Frameworks"
 	)
 
-	add_custom_command(TARGET CemuBin POST_BUILD
-		COMMAND install_name_tool
-			-change @rpath/libusb-1.0.0.dylib
-					@executable_path/../Frameworks/libusb-1.0.0.dylib
-					"$<TARGET_FILE:CemuBin>"
-	)
+	if (ENABLE_LIBUSB)
+    add_custom_command(TARGET CemuBin POST_BUILD
+      COMMAND install_name_tool
+        -change @rpath/libusb-1.0.0.dylib
+            @executable_path/../Frameworks/libusb-1.0.0.dylib
+            "$<TARGET_FILE:CemuBin>"
+    )
+  endif()
 else()
     if(APPLE)
         find_library(MOLTENVK_LIBRARY
diff --git a/src/Cafe/CMakeLists.txt b/src/Cafe/CMakeLists.txt
index 78a8cce0..e5e41143 100644
--- a/src/Cafe/CMakeLists.txt
+++ b/src/Cafe/CMakeLists.txt
@@ -471,8 +471,6 @@ add_library(CemuCafe
   OS/libs/nsyshid/Whitelist.h
   OS/libs/nsyshid/BackendEmulated.cpp
   OS/libs/nsyshid/BackendEmulated.h
-  OS/libs/nsyshid/BackendLibusb.cpp
-  OS/libs/nsyshid/BackendLibusb.h
   OS/libs/nsyshid/Dimensions.cpp
   OS/libs/nsyshid/Dimensions.h
   OS/libs/nsyshid/Infinity.cpp
@@ -617,6 +615,13 @@ set_property(TARGET CemuCafe PROPERTY MSVC_RUNTIME_LIBRARY "MultiThreaded$<$<CON
 
 cemu_use_precompiled_header(CemuCafe)
 
+if (ENABLE_LIBUSB)
+  target_sources(CemuCafe PRIVATE
+    OS/libs/nsyshid/BackendLibusb.cpp
+    OS/libs/nsyshid/BackendLibusb.h
+  )
+endif()
+
 target_include_directories(CemuCafe PUBLIC "../")
 
 if (glslang_VERSION VERSION_LESS "15.0.0")
@@ -645,17 +650,19 @@ if (ENABLE_WAYLAND)
   target_link_libraries(CemuCafe PUBLIC Wayland::Client)
 endif()
 
-if (ENABLE_VCPKG)
-  if(WIN32)
-    set(PKG_CONFIG_EXECUTABLE "${VCPKG_INSTALLED_DIR}/x64-windows/tools/pkgconf/pkgconf.exe")
-  endif()
-  find_package(PkgConfig REQUIRED)
-  pkg_check_modules(libusb REQUIRED IMPORTED_TARGET libusb-1.0)
-  target_link_libraries(CemuCafe PRIVATE PkgConfig::libusb)
-else ()
-  find_package(libusb MODULE REQUIRED)
-  target_link_libraries(CemuCafe PRIVATE libusb::libusb)
-endif ()
+if (ENABLE_LIBUSB)
+  if (ENABLE_VCPKG)
+    if(WIN32)
+      set(PKG_CONFIG_EXECUTABLE "${VCPKG_INSTALLED_DIR}/x64-windows/tools/pkgconf/pkgconf.exe")
+    endif()
+    find_package(PkgConfig REQUIRED)
+    pkg_check_modules(libusb REQUIRED IMPORTED_TARGET libusb-1.0)
+    target_link_libraries(CemuCafe PRIVATE PkgConfig::libusb)
+  else ()
+    find_package(libusb MODULE REQUIRED)
+    target_link_libraries(CemuCafe PRIVATE libusb::libusb)
+  endif ()
+endif()
 
 if(WIN32)
 	target_link_libraries(CemuCafe PRIVATE iphlpapi)
diff --git a/src/Cafe/OS/libs/nsyshid/AttachDefaultBackends.cpp b/src/Cafe/OS/libs/nsyshid/AttachDefaultBackends.cpp
index 67eb0240..ec0e2cd8 100644
--- a/src/Cafe/OS/libs/nsyshid/AttachDefaultBackends.cpp
+++ b/src/Cafe/OS/libs/nsyshid/AttachDefaultBackends.cpp
@@ -1,12 +1,15 @@
 #include "nsyshid.h"
 #include "Backend.h"
 #include "BackendEmulated.h"
+#ifdef HAS_LIBUSB
 #include "BackendLibusb.h"
+#endif
 
 namespace nsyshid::backend
 {
 	void AttachDefaultBackends()
 	{
+	#ifdef HAS_LIBUSB
 		// add libusb backend
 		{
 			auto backendLibusb = std::make_shared<backend::libusb::BackendLibusb>();
@@ -15,6 +18,7 @@ namespace nsyshid::backend
 				AttachBackend(backendLibusb);
 			}
 		}
+	#endif
 	   // add emulated backend
 		{
 			auto backendEmulated = std::make_shared<backend::emulated::BackendEmulated>();
diff --git a/src/Cafe/OS/libs/nsyshid/BackendEmulated.cpp b/src/Cafe/OS/libs/nsyshid/BackendEmulated.cpp
index a5eb95c1..e6b9fd9d 100644
--- a/src/Cafe/OS/libs/nsyshid/BackendEmulated.cpp
+++ b/src/Cafe/OS/libs/nsyshid/BackendEmulated.cpp
@@ -29,6 +29,7 @@ namespace nsyshid::backend::emulated
 			auto device = std::make_shared<SkylanderPortalDevice>();
 			AttachDevice(device);
 		}
+	#ifdef HAS_LIBUSB
 		else if (auto usb_portal = FindDeviceById(0x1430, 0x1F17))
 		{
 			cemuLog_logDebug(LogType::Force, "Attaching Xbox 360 Portal");
@@ -36,6 +37,7 @@ namespace nsyshid::backend::emulated
 			auto device = std::make_shared<SkylanderXbox360PortalLibusb>(usb_portal);
 			AttachDevice(device);
 		}
+	#endif
 		if (GetConfig().emulated_usb_devices.emulate_infinity_base && !FindDeviceById(0x0E6F, 0x0129))
 		{
 			cemuLog_logDebug(LogType::Force, "Attaching Emulated Base");
diff --git a/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.cpp b/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.cpp
index eba8ff9e..0c528094 100644
--- a/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.cpp
+++ b/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.cpp
@@ -2,6 +2,7 @@
 
 namespace nsyshid
 {
+	#ifdef HAS_LIBUSB
 	SkylanderXbox360PortalLibusb::SkylanderXbox360PortalLibusb(std::shared_ptr<Device> usbPortal)
 		: Device(0x1430, 0x0150, 1, 2, 0)
 	{
@@ -157,4 +158,5 @@ namespace nsyshid
 	{
 		return true;
 	}
+	#endif
 } // namespace nsyshid
\ No newline at end of file
diff --git a/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.h b/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.h
index 901c63f9..b92cffcc 100644
--- a/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.h
+++ b/src/Cafe/OS/libs/nsyshid/SkylanderXbox360.h
@@ -1,11 +1,14 @@
 #pragma once
 
 #include "nsyshid.h"
+#ifdef HAS_LIBUSB
 #include "BackendLibusb.h"
 #include "g721/g721.h"
+#endif
 
 namespace nsyshid
 {
+	#ifdef HAS_LIBUSB
 	class SkylanderXbox360PortalLibusb final : public Device {
 	  public:
 		SkylanderXbox360PortalLibusb(std::shared_ptr<Device> usbPortal);
@@ -40,6 +43,7 @@ namespace nsyshid
 		bool m_IsOpened;
 		struct g72x_state m_state;
 	};
+	#endif
 
 	constexpr uint8 XBOX_DATA_HEADER[] = { 0x0B, 0x14 };
 	constexpr uint8 XBOX_AUDIO_DATA_HEADER[] = { 0x0B, 0x17 };
diff --git a/src/input/CMakeLists.txt b/src/input/CMakeLists.txt
index d24a5ca0..4e5a990f 100644
--- a/src/input/CMakeLists.txt
+++ b/src/input/CMakeLists.txt
@@ -23,10 +23,6 @@ add_library(CemuInput
 	api/Keyboard/KeyboardControllerProvider.cpp
 	api/Keyboard/KeyboardController.cpp
 	api/Keyboard/KeyboardController.h
-	api/GameCube/GameCubeController.cpp
-	api/GameCube/GameCubeControllerProvider.h
-	api/GameCube/GameCubeControllerProvider.cpp
-	api/GameCube/GameCubeController.h
 	emulated/ProController.cpp
 	emulated/EmulatedController.h
 	emulated/EmulatedController.cpp
@@ -45,6 +41,15 @@ set_property(TARGET CemuInput PROPERTY MSVC_RUNTIME_LIBRARY "MultiThreaded$<$<CO
 
 cemu_use_precompiled_header(CemuInput)
 
+if (ENABLE_LIBUSB)
+	target_sources(CemuInput PRIVATE
+		api/GameCube/GameCubeController.cpp
+		api/GameCube/GameCubeControllerProvider.h
+		api/GameCube/GameCubeControllerProvider.cpp
+		api/GameCube/GameCubeController.h
+	)
+endif()
+
 if(WIN32)
 	# XInput
 	target_sources(CemuInput PRIVATE
diff --git a/src/input/ControllerFactory.cpp b/src/input/ControllerFactory.cpp
index 70a85a2d..1284c6b1 100644
--- a/src/input/ControllerFactory.cpp
+++ b/src/input/ControllerFactory.cpp
@@ -83,7 +83,7 @@ ControllerPtr ControllerFactory::CreateController(InputAPI::Type api, std::strin
 			return std::make_shared<DSUController>(index);
 		}
 #endif
-#if HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
 	case InputAPI::GameCube:
 		{
 			const auto index = uuid.find_first_of('_');
@@ -165,7 +165,7 @@ ControllerProviderPtr ControllerFactory::CreateControllerProvider(InputAPI::Type
 		}
 
 #endif
-#if HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
 	case InputAPI::GameCube:
 		return std::make_shared<GameCubeControllerProvider>();
 #endif
diff --git a/src/input/InputManager.cpp b/src/input/InputManager.cpp
index 64b238fc..5b228414 100644
--- a/src/input/InputManager.cpp
+++ b/src/input/InputManager.cpp
@@ -40,7 +40,7 @@ InputManager::InputManager()
 #if HAS_DSU
 	create_provider<DSUControllerProvider>();
 #endif
-#if HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
 	create_provider<GameCubeControllerProvider>();
 #endif
 #if HAS_WIIMOTE
diff --git a/src/input/api/GameCube/GameCubeController.cpp b/src/input/api/GameCube/GameCubeController.cpp
index 538e6241..910a513e 100644
--- a/src/input/api/GameCube/GameCubeController.cpp
+++ b/src/input/api/GameCube/GameCubeController.cpp
@@ -1,6 +1,6 @@
 #include "input/api/GameCube/GameCubeController.h"
 
-#ifdef HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
 
 GameCubeController::GameCubeController(uint32 adapter, uint32 index)
 	: base_type(fmt::format("{}_{}", adapter, index), fmt::format("Controller {}", index + 1)), m_adapter(adapter),
diff --git a/src/input/api/GameCube/GameCubeController.h b/src/input/api/GameCube/GameCubeController.h
index fd7fe237..d027eee0 100644
--- a/src/input/api/GameCube/GameCubeController.h
+++ b/src/input/api/GameCube/GameCubeController.h
@@ -3,7 +3,7 @@
 #include "input/api/Controller.h"
 #include "input/api/GameCube/GameCubeControllerProvider.h"
 
-#ifdef HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
 
 class GameCubeController : public Controller<GameCubeControllerProvider>
 {
diff --git a/src/input/api/GameCube/GameCubeControllerProvider.cpp b/src/input/api/GameCube/GameCubeControllerProvider.cpp
index f3a2f20d..60689568 100644
--- a/src/input/api/GameCube/GameCubeControllerProvider.cpp
+++ b/src/input/api/GameCube/GameCubeControllerProvider.cpp
@@ -2,7 +2,7 @@
 #include "input/api/GameCube/GameCubeController.h"
 #include "util/libusbWrapper/libusbWrapper.h"
 
-#if HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
 
 constexpr uint16_t kVendorId = 0x57e, kProductId = 0x337;
 
diff --git a/src/input/api/GameCube/GameCubeControllerProvider.h b/src/input/api/GameCube/GameCubeControllerProvider.h
index 08f847a0..d4e19d92 100644
--- a/src/input/api/GameCube/GameCubeControllerProvider.h
+++ b/src/input/api/GameCube/GameCubeControllerProvider.h
@@ -1,9 +1,10 @@
 #pragma once
 
-#include "util/libusbWrapper/libusbWrapper.h"
 #include "input/api/ControllerProvider.h"
 
-#ifdef HAS_GAMECUBE
+#if defined(HAS_GAMECUBE) && HAS_GAMECUBE && defined(HAS_LIBUSB)
+
+#include "util/libusbWrapper/libusbWrapper.h"
 
 class GameCubeControllerProvider : public ControllerProviderBase
 {
diff --git a/src/util/CMakeLists.txt b/src/util/CMakeLists.txt
index 390e9c10..c170adc5 100644
--- a/src/util/CMakeLists.txt
+++ b/src/util/CMakeLists.txt
@@ -43,8 +43,6 @@ add_library(CemuUtil
   ImageWriter/tga.h
   IniParser/IniParser.cpp
   IniParser/IniParser.h
-  libusbWrapper/libusbWrapper.cpp
-  libusbWrapper/libusbWrapper.h
   math/glm.h
   math/quaternion.h
   math/vector2.h
@@ -91,6 +89,13 @@ set_property(TARGET CemuUtil PROPERTY MSVC_RUNTIME_LIBRARY "MultiThreaded$<$<CON
 
 cemu_use_precompiled_header(CemuUtil)
 
+if (ENABLE_LIBUSB)
+  target_sources(CemuUtil PRIVATE
+    libusbWrapper/libusbWrapper.cpp
+    libusbWrapper/libusbWrapper.h
+  )
+endif()
+
 target_include_directories(CemuUtil PUBLIC "../")
 
 target_link_libraries(CemuUtil PRIVATE