diff --git a/Source/Core/DolphinLib.props b/Source/Core/DolphinLib.props
index 35d170a0d54..5049ac785f6 100644
--- a/Source/Core/DolphinLib.props
+++ b/Source/Core/DolphinLib.props
@@ -749,6 +749,7 @@
     <ClInclude Include="VideoCommon\Present.h" />
     <ClInclude Include="VideoCommon\RenderState.h" />
     <ClInclude Include="VideoCommon\ShaderCache.h" />
+    <ClInclude Include="VideoCommon\ShaderCompileUtils.h" />
     <ClInclude Include="VideoCommon\ShaderGenCommon.h" />
     <ClInclude Include="VideoCommon\Spirv.h" />
     <ClInclude Include="VideoCommon\Statistics.h" />
@@ -1396,6 +1397,7 @@
     <ClCompile Include="VideoCommon\Present.cpp" />
     <ClCompile Include="VideoCommon\RenderState.cpp" />
     <ClCompile Include="VideoCommon\ShaderCache.cpp" />
+    <ClCompile Include="VideoCommon\ShaderCompileUtils.cpp" />
     <ClCompile Include="VideoCommon\ShaderGenCommon.cpp" />
     <ClCompile Include="VideoCommon\Spirv.cpp" />
     <ClCompile Include="VideoCommon\Statistics.cpp" />
diff --git a/Source/Core/VideoBackends/D3D/D3DGfx.cpp b/Source/Core/VideoBackends/D3D/D3DGfx.cpp
index a58293ef6bd..dc7ee37908e 100644
--- a/Source/Core/VideoBackends/D3D/D3DGfx.cpp
+++ b/Source/Core/VideoBackends/D3D/D3DGfx.cpp
@@ -71,9 +71,10 @@ Gfx::CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* depth
 }
 
 std::unique_ptr<AbstractShader>
-Gfx::CreateShaderFromSource(ShaderStage stage, std::string_view source, std::string_view name)
+Gfx::CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                            VideoCommon::ShaderIncluder* shader_includer, std::string_view name)
 {
-  auto bytecode = DXShader::CompileShader(D3D::feature_level, stage, source);
+  auto bytecode = DXShader::CompileShader(D3D::feature_level, stage, source, shader_includer);
   if (!bytecode)
     return nullptr;
 
diff --git a/Source/Core/VideoBackends/D3D/D3DGfx.h b/Source/Core/VideoBackends/D3D/D3DGfx.h
index 96c5f316be0..1c65485c952 100644
--- a/Source/Core/VideoBackends/D3D/D3DGfx.h
+++ b/Source/Core/VideoBackends/D3D/D3DGfx.h
@@ -31,8 +31,10 @@ public:
                                                  std::string_view name) override;
   std::unique_ptr<AbstractStagingTexture>
   CreateStagingTexture(StagingTextureType type, const TextureConfig& config) override;
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/D3D12/D3D12Gfx.cpp b/Source/Core/VideoBackends/D3D12/D3D12Gfx.cpp
index 265ec06e6c1..cc89b492e68 100644
--- a/Source/Core/VideoBackends/D3D12/D3D12Gfx.cpp
+++ b/Source/Core/VideoBackends/D3D12/D3D12Gfx.cpp
@@ -68,9 +68,10 @@ Gfx::CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* depth
 }
 
 std::unique_ptr<AbstractShader>
-Gfx::CreateShaderFromSource(ShaderStage stage, std::string_view source, std::string_view name)
+Gfx::CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                            VideoCommon::ShaderIncluder* shader_includer, std::string_view name)
 {
-  return DXShader::CreateFromSource(stage, source, name);
+  return DXShader::CreateFromSource(stage, source, shader_includer, name);
 }
 
 std::unique_ptr<AbstractShader> Gfx::CreateShaderFromBinary(ShaderStage stage, const void* data,
diff --git a/Source/Core/VideoBackends/D3D12/D3D12Gfx.h b/Source/Core/VideoBackends/D3D12/D3D12Gfx.h
index ce574a36901..478fa7f5c0b 100644
--- a/Source/Core/VideoBackends/D3D12/D3D12Gfx.h
+++ b/Source/Core/VideoBackends/D3D12/D3D12Gfx.h
@@ -36,8 +36,10 @@ public:
   CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* depth_attachment,
                     std::vector<AbstractTexture*> additional_color_attachments) override;
 
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/D3D12/DX12Shader.cpp b/Source/Core/VideoBackends/D3D12/DX12Shader.cpp
index 61550d2a686..e437533510b 100644
--- a/Source/Core/VideoBackends/D3D12/DX12Shader.cpp
+++ b/Source/Core/VideoBackends/D3D12/DX12Shader.cpp
@@ -29,9 +29,10 @@ std::unique_ptr<DXShader> DXShader::CreateFromBytecode(ShaderStage stage, Binary
 }
 
 std::unique_ptr<DXShader> DXShader::CreateFromSource(ShaderStage stage, std::string_view source,
+                                                     VideoCommon::ShaderIncluder* shader_includer,
                                                      std::string_view name)
 {
-  auto bytecode = CompileShader(g_dx_context->GetFeatureLevel(), stage, source);
+  auto bytecode = CompileShader(g_dx_context->GetFeatureLevel(), stage, source, shader_includer);
   if (!bytecode)
     return nullptr;
 
diff --git a/Source/Core/VideoBackends/D3D12/DX12Shader.h b/Source/Core/VideoBackends/D3D12/DX12Shader.h
index 8c4c9292b41..d5090e57405 100644
--- a/Source/Core/VideoBackends/D3D12/DX12Shader.h
+++ b/Source/Core/VideoBackends/D3D12/DX12Shader.h
@@ -23,6 +23,7 @@ public:
   static std::unique_ptr<DXShader> CreateFromBytecode(ShaderStage stage, BinaryData bytecode,
                                                       std::string_view name);
   static std::unique_ptr<DXShader> CreateFromSource(ShaderStage stage, std::string_view source,
+                                                    VideoCommon::ShaderIncluder* shader_includer,
                                                     std::string_view name);
 
 private:
diff --git a/Source/Core/VideoBackends/D3DCommon/Shader.cpp b/Source/Core/VideoBackends/D3DCommon/Shader.cpp
index 369af7c8a13..bf4af33b954 100644
--- a/Source/Core/VideoBackends/D3DCommon/Shader.cpp
+++ b/Source/Core/VideoBackends/D3DCommon/Shader.cpp
@@ -20,6 +20,7 @@
 #include "Common/StringUtil.h"
 #include "Common/Version.h"
 
+#include "VideoCommon/ShaderCompileUtils.h"
 #include "VideoCommon/Spirv.h"
 #include "VideoCommon/VideoBackendBase.h"
 #include "VideoCommon/VideoConfig.h"
@@ -35,6 +36,9 @@ namespace
 constexpr std::string_view SHADER_HEADER = R"(
   // Target GLSL 4.5.
   #version 450 core
+
+  #extension GL_ARB_shading_language_include : enable
+
   #define ATTRIBUTE_LOCATION(x) layout(location = x)
   #define FRAGMENT_OUTPUT_LOCATION(x) layout(location = x)
   #define FRAGMENT_OUTPUT_LOCATION_INDEXED(x, y) layout(location = x, index = y)
@@ -107,14 +111,16 @@ std::optional<std::string> GetHLSLFromSPIRV(SPIRV::CodeVector spv, D3D_FEATURE_L
   return compiler.compile();
 }
 
-std::optional<SPIRV::CodeVector> GetSpirv(ShaderStage stage, std::string_view source)
+std::optional<SPIRV::CodeVector> GetSpirv(ShaderStage stage, std::string_view source,
+                                          glslang::TShader::Includer* shader_includer)
 {
   switch (stage)
   {
   case ShaderStage::Vertex:
   {
     const auto full_source = fmt::format("{}{}", SHADER_HEADER, source);
-    return SPIRV::CompileVertexShader(full_source, APIType::D3D, glslang::EShTargetSpv_1_0);
+    return SPIRV::CompileVertexShader(full_source, APIType::D3D, glslang::EShTargetSpv_1_0,
+                                      shader_includer);
   }
 
   case ShaderStage::Geometry:
@@ -126,13 +132,15 @@ std::optional<SPIRV::CodeVector> GetSpirv(ShaderStage stage, std::string_view so
   case ShaderStage::Pixel:
   {
     const auto full_source = fmt::format("{}{}", SHADER_HEADER, source);
-    return SPIRV::CompileFragmentShader(full_source, APIType::D3D, glslang::EShTargetSpv_1_0);
+    return SPIRV::CompileFragmentShader(full_source, APIType::D3D, glslang::EShTargetSpv_1_0,
+                                        shader_includer);
   }
 
   case ShaderStage::Compute:
   {
     const auto full_source = fmt::format("{}{}", COMPUTE_SHADER_HEADER, source);
-    return SPIRV::CompileComputeShader(full_source, APIType::D3D, glslang::EShTargetSpv_1_0);
+    return SPIRV::CompileComputeShader(full_source, APIType::D3D, glslang::EShTargetSpv_1_0,
+                                       shader_includer);
   }
   };
 
@@ -140,13 +148,14 @@ std::optional<SPIRV::CodeVector> GetSpirv(ShaderStage stage, std::string_view so
 }
 
 std::optional<std::string> GetHLSL(D3D_FEATURE_LEVEL feature_level, ShaderStage stage,
-                                   std::string_view source)
+                                   std::string_view source,
+                                   VideoCommon::ShaderIncluder* shader_includer)
 {
   if (stage == ShaderStage::Geometry)
   {
     return std::string{source};
   }
-  else if (const auto spirv = GetSpirv(stage, source))
+  else if (const auto spirv = GetSpirv(stage, source, shader_includer))
   {
     return GetHLSLFromSPIRV(std::move(*spirv), feature_level);
   }
@@ -230,10 +239,11 @@ static const char* GetCompileTarget(D3D_FEATURE_LEVEL feature_level, ShaderStage
   }
 }
 
-std::optional<Shader::BinaryData> Shader::CompileShader(D3D_FEATURE_LEVEL feature_level,
-                                                        ShaderStage stage, std::string_view source)
+std::optional<Shader::BinaryData>
+Shader::CompileShader(D3D_FEATURE_LEVEL feature_level, ShaderStage stage, std::string_view source,
+                      VideoCommon::ShaderIncluder* shader_includer)
 {
-  const auto hlsl = GetHLSL(feature_level, stage, source);
+  const auto hlsl = GetHLSL(feature_level, stage, source, shader_includer);
   if (!hlsl)
     return std::nullopt;
 
@@ -260,7 +270,7 @@ std::optional<Shader::BinaryData> Shader::CompileShader(D3D_FEATURE_LEVEL featur
     file << "Dolphin Version: " + Common::GetScmRevStr() + "\n";
     file << "Video Backend: " + g_video_backend->GetDisplayName();
 
-    if (const auto spirv = GetSpirv(stage, source))
+    if (const auto spirv = GetSpirv(stage, source, shader_includer))
     {
       file << "\nOriginal Source: \n";
       file << source << std::endl;
diff --git a/Source/Core/VideoBackends/D3DCommon/Shader.h b/Source/Core/VideoBackends/D3DCommon/Shader.h
index c450bf74cb8..0018534f1df 100644
--- a/Source/Core/VideoBackends/D3DCommon/Shader.h
+++ b/Source/Core/VideoBackends/D3DCommon/Shader.h
@@ -20,7 +20,8 @@ public:
   BinaryData GetBinary() const override;
 
   static std::optional<BinaryData> CompileShader(D3D_FEATURE_LEVEL feature_level, ShaderStage stage,
-                                                 std::string_view source);
+                                                 std::string_view source,
+                                                 VideoCommon::ShaderIncluder* shader_includer);
 
   static BinaryData CreateByteCode(const void* data, size_t length);
 
diff --git a/Source/Core/VideoBackends/Metal/MTLGfx.h b/Source/Core/VideoBackends/Metal/MTLGfx.h
index f1916766a6d..fc9fca0c68e 100644
--- a/Source/Core/VideoBackends/Metal/MTLGfx.h
+++ b/Source/Core/VideoBackends/Metal/MTLGfx.h
@@ -31,8 +31,10 @@ public:
   CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* depth_attachment,
                     std::vector<AbstractTexture*> additional_color_attachments) override;
 
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/Metal/MTLGfx.mm b/Source/Core/VideoBackends/Metal/MTLGfx.mm
index d4236bd5032..4b744fe5111 100644
--- a/Source/Core/VideoBackends/Metal/MTLGfx.mm
+++ b/Source/Core/VideoBackends/Metal/MTLGfx.mm
@@ -120,11 +120,12 @@ Metal::Gfx::CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture
 
 // MARK: Pipeline Creation
 
-std::unique_ptr<AbstractShader> Metal::Gfx::CreateShaderFromSource(ShaderStage stage,
-                                                                   std::string_view source,
-                                                                   std::string_view name)
+std::unique_ptr<AbstractShader>
+Metal::Gfx::CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                                   VideoCommon::ShaderIncluder* shader_includer,
+                                   std::string_view name)
 {
-  std::optional<std::string> msl = Util::TranslateShaderToMSL(stage, source);
+  std::optional<std::string> msl = Util::TranslateShaderToMSL(stage, source, shader_includer);
   if (!msl.has_value())
   {
     PanicAlertFmt("Failed to convert shader {} to MSL", name);
diff --git a/Source/Core/VideoBackends/Metal/MTLUtil.h b/Source/Core/VideoBackends/Metal/MTLUtil.h
index 812ce39e5a4..1752c82aa5c 100644
--- a/Source/Core/VideoBackends/Metal/MTLUtil.h
+++ b/Source/Core/VideoBackends/Metal/MTLUtil.h
@@ -54,7 +54,8 @@ static inline bool HasStencil(AbstractTextureFormat format)
   return format == AbstractTextureFormat::D24_S8 || format == AbstractTextureFormat::D32F_S8;
 }
 
-std::optional<std::string> TranslateShaderToMSL(ShaderStage stage, std::string_view source);
+std::optional<std::string> TranslateShaderToMSL(ShaderStage stage, std::string_view source,
+                                                VideoCommon::ShaderIncluder* shader_includer);
 
 }  // namespace Util
 }  // namespace Metal
diff --git a/Source/Core/VideoBackends/Metal/MTLUtil.mm b/Source/Core/VideoBackends/Metal/MTLUtil.mm
index 05e2115ab31..ad52653ee3d 100644
--- a/Source/Core/VideoBackends/Metal/MTLUtil.mm
+++ b/Source/Core/VideoBackends/Metal/MTLUtil.mm
@@ -13,6 +13,7 @@
 
 #include "VideoCommon/Constants.h"
 #include "VideoCommon/DriverDetails.h"
+#include "VideoCommon/ShaderCompileUtils.h"
 #include "VideoCommon/Spirv.h"
 
 Metal::DeviceFeatures Metal::g_features;
@@ -490,8 +491,9 @@ MakeResourceBinding(spv::ExecutionModel stage, u32 set, u32 binding,  //
   return resource;
 }
 
-std::optional<std::string> Metal::Util::TranslateShaderToMSL(ShaderStage stage,
-                                                             std::string_view source)
+std::optional<std::string>
+Metal::Util::TranslateShaderToMSL(ShaderStage stage, std::string_view source,
+                                  VideoCommon::ShaderIncluder* shader_includer)
 {
   std::string full_source;
 
@@ -514,16 +516,19 @@ std::optional<std::string> Metal::Util::TranslateShaderToMSL(ShaderStage stage,
   switch (stage)
   {
   case ShaderStage::Vertex:
-    code = SPIRV::CompileVertexShader(full_source, APIType::Metal, glslang::EShTargetSpv_1_5);
+    code = SPIRV::CompileVertexShader(full_source, APIType::Metal, glslang::EShTargetSpv_1_5,
+                                      shader_includer);
     break;
   case ShaderStage::Geometry:
     PanicAlertFmt("Tried to compile geometry shader for Metal, but Metal doesn't support them!");
     break;
   case ShaderStage::Pixel:
-    code = SPIRV::CompileFragmentShader(full_source, APIType::Metal, glslang::EShTargetSpv_1_5);
+    code = SPIRV::CompileFragmentShader(full_source, APIType::Metal, glslang::EShTargetSpv_1_5,
+                                        shader_includer);
     break;
   case ShaderStage::Compute:
-    code = SPIRV::CompileComputeShader(full_source, APIType::Metal, glslang::EShTargetSpv_1_5);
+    code = SPIRV::CompileComputeShader(full_source, APIType::Metal, glslang::EShTargetSpv_1_5,
+                                       shader_includer);
     break;
   }
   if (!code.has_value())
diff --git a/Source/Core/VideoBackends/Null/NullGfx.cpp b/Source/Core/VideoBackends/Null/NullGfx.cpp
index 61822d3c83b..09c605ee18e 100644
--- a/Source/Core/VideoBackends/Null/NullGfx.cpp
+++ b/Source/Core/VideoBackends/Null/NullGfx.cpp
@@ -53,6 +53,7 @@ public:
 
 std::unique_ptr<AbstractShader>
 NullGfx::CreateShaderFromSource(ShaderStage stage, [[maybe_unused]] std::string_view source,
+                                [[maybe_unused]] VideoCommon::ShaderIncluder* shader_includer,
                                 [[maybe_unused]] std::string_view name)
 {
   return std::make_unique<NullShader>(stage);
diff --git a/Source/Core/VideoBackends/Null/NullGfx.h b/Source/Core/VideoBackends/Null/NullGfx.h
index 5e1a25fef74..d811a48cbc4 100644
--- a/Source/Core/VideoBackends/Null/NullGfx.h
+++ b/Source/Core/VideoBackends/Null/NullGfx.h
@@ -25,8 +25,10 @@ public:
   CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* depth_attachment,
                     std::vector<AbstractTexture*> additional_color_attachments) override;
 
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/OGL/OGLGfx.cpp b/Source/Core/VideoBackends/OGL/OGLGfx.cpp
index 015bb719940..064856804f4 100644
--- a/Source/Core/VideoBackends/OGL/OGLGfx.cpp
+++ b/Source/Core/VideoBackends/OGL/OGLGfx.cpp
@@ -231,9 +231,10 @@ OGLGfx::CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* de
 }
 
 std::unique_ptr<AbstractShader>
-OGLGfx::CreateShaderFromSource(ShaderStage stage, std::string_view source, std::string_view name)
+OGLGfx::CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                               VideoCommon::ShaderIncluder* shader_includer, std::string_view name)
 {
-  return OGLShader::CreateFromSource(stage, source, name);
+  return OGLShader::CreateFromSource(stage, source, shader_includer, name);
 }
 
 std::unique_ptr<AbstractShader>
diff --git a/Source/Core/VideoBackends/OGL/OGLGfx.h b/Source/Core/VideoBackends/OGL/OGLGfx.h
index 79144880134..a76008fdc96 100644
--- a/Source/Core/VideoBackends/OGL/OGLGfx.h
+++ b/Source/Core/VideoBackends/OGL/OGLGfx.h
@@ -25,8 +25,10 @@ public:
                                                  std::string_view name) override;
   std::unique_ptr<AbstractStagingTexture>
   CreateStagingTexture(StagingTextureType type, const TextureConfig& config) override;
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/OGL/OGLShader.cpp b/Source/Core/VideoBackends/OGL/OGLShader.cpp
index 9c100a5e30e..3d6c4ed860f 100644
--- a/Source/Core/VideoBackends/OGL/OGLShader.cpp
+++ b/Source/Core/VideoBackends/OGL/OGLShader.cpp
@@ -3,12 +3,110 @@
 
 #include "VideoBackends/OGL/OGLShader.h"
 
+#include <algorithm>
+#include <cctype>
+
 #include "VideoBackends/OGL/ProgramShaderCache.h"
 
+#include "VideoCommon/ShaderCompileUtils.h"
+#include "VideoCommon/ShaderGenCommon.h"
 #include "VideoCommon/VideoConfig.h"
 
 namespace OGL
 {
+namespace
+{
+std::string ResolveIncludeStatements(glslang::TShader::Includer* shader_includer,
+                                     std::string_view source, const char* includer_name = "",
+                                     std::size_t depth = 1)
+{
+  if (!shader_includer)
+  {
+    return std::string{source};
+  }
+
+  std::string source_str(source);
+  std::istringstream iss(source_str);
+
+  ShaderCode output;
+  std::string line;
+  while (std::getline(iss, line))
+  {
+    if (line.empty())
+    {
+      output.Write("{}\n", line);
+      continue;
+    }
+
+    std::string_view include_preprocessor = "#include";
+    if (!line.starts_with(include_preprocessor))
+    {
+      output.Write("{}\n", line);
+      continue;
+    }
+
+    const std::string after_include = line.substr(include_preprocessor.size());
+
+    bool local_include = true;
+    std::string_view filename;
+    // First non-whitespace character after include
+    const std::string::const_iterator non_whitespace_iter = std::find_if_not(
+        after_include.begin(), after_include.end(), [](char ch) { return std::isspace(ch); });
+    if (*non_whitespace_iter == '<')
+    {
+      const auto after_less = std::next(non_whitespace_iter);
+      if (after_less == after_include.end())
+      {
+        // Found less-than at the end, malformed
+        output.Write("{}\n", line);
+        continue;
+      }
+      const auto end_iter = std::find(after_less, after_include.end(), '>');
+      if (end_iter == after_include.end())
+      {
+        // Include spans multiple lines or is malformed, just pass it along
+        output.Write("{}\n", line);
+        continue;
+      }
+      filename = std::string_view(after_less, end_iter);
+      local_include = false;
+    }
+    else if (*non_whitespace_iter == '"')
+    {
+      const auto after_quote = std::next(non_whitespace_iter);
+      if (after_quote == after_include.end())
+      {
+        // Found quote at the end, malformed
+        output.Write("{}\n", line);
+        continue;
+      }
+      const auto end_iter = std::find(after_quote, after_include.end(), '"');
+      if (end_iter == after_include.end())
+      {
+        // Include spans multiple lines or is malformed, just pass it along
+        output.Write("{}\n", line);
+        continue;
+      }
+      filename = std::string_view(after_quote, end_iter);
+    }
+
+    const std::string header_path = std::string{filename};
+    auto include_result =
+        local_include ? shader_includer->includeLocal(header_path.c_str(), includer_name, depth) :
+                        shader_includer->includeSystem(header_path.c_str(), includer_name, depth);
+    if (!include_result)
+    {
+      output.Write("{}\n", line);
+      continue;
+    }
+
+    output.Write("{}", ResolveIncludeStatements(shader_includer, include_result->headerData,
+                                                header_path.c_str(), ++depth));
+  }
+
+  return output.GetBuffer();
+}
+}  // namespace
 static GLenum GetGLShaderTypeForStage(ShaderStage stage)
 {
   switch (stage)
@@ -57,9 +155,12 @@ OGLShader::~OGLShader()
 }
 
 std::unique_ptr<OGLShader> OGLShader::CreateFromSource(ShaderStage stage, std::string_view source,
+                                                       VideoCommon::ShaderIncluder* shader_includer,
                                                        std::string_view name)
 {
-  std::string source_str(source);
+  // Note: while the source will all be available, any errors will not
+  // reference the correct paths
+  std::string source_str = ResolveIncludeStatements(shader_includer, source);
   std::string name_str(name);
   if (stage != ShaderStage::Compute)
   {
diff --git a/Source/Core/VideoBackends/OGL/OGLShader.h b/Source/Core/VideoBackends/OGL/OGLShader.h
index 06b9449ac63..2554c744b85 100644
--- a/Source/Core/VideoBackends/OGL/OGLShader.h
+++ b/Source/Core/VideoBackends/OGL/OGLShader.h
@@ -29,6 +29,7 @@ public:
   const std::string& GetSource() const { return m_source; }
 
   static std::unique_ptr<OGLShader> CreateFromSource(ShaderStage stage, std::string_view source,
+                                                     VideoCommon::ShaderIncluder* shader_includer,
                                                      std::string_view name);
 
 private:
diff --git a/Source/Core/VideoBackends/Software/SWGfx.cpp b/Source/Core/VideoBackends/Software/SWGfx.cpp
index c758d1819eb..fba9faf7e5e 100644
--- a/Source/Core/VideoBackends/Software/SWGfx.cpp
+++ b/Source/Core/VideoBackends/Software/SWGfx.cpp
@@ -78,6 +78,7 @@ public:
 
 std::unique_ptr<AbstractShader>
 SWGfx::CreateShaderFromSource(ShaderStage stage, [[maybe_unused]] std::string_view source,
+                              [[maybe_unused]] VideoCommon::ShaderIncluder* shader_includer,
                               [[maybe_unused]] std::string_view name)
 {
   return std::make_unique<SWShader>(stage);
diff --git a/Source/Core/VideoBackends/Software/SWGfx.h b/Source/Core/VideoBackends/Software/SWGfx.h
index 2ea36de5d8a..f901f2936d9 100644
--- a/Source/Core/VideoBackends/Software/SWGfx.h
+++ b/Source/Core/VideoBackends/Software/SWGfx.h
@@ -28,8 +28,10 @@ public:
 
   bool BindBackbuffer(const ClearColor& clear_color = {}) override;
 
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/Vulkan/ShaderCompiler.cpp b/Source/Core/VideoBackends/Vulkan/ShaderCompiler.cpp
index 86826f72801..13dbe0e0b74 100644
--- a/Source/Core/VideoBackends/Vulkan/ShaderCompiler.cpp
+++ b/Source/Core/VideoBackends/Vulkan/ShaderCompiler.cpp
@@ -8,6 +8,7 @@
 
 #include "VideoBackends/Vulkan/VulkanContext.h"
 #include "VideoCommon/DriverDetails.h"
+#include "VideoCommon/ShaderCompileUtils.h"
 #include "VideoCommon/Spirv.h"
 
 namespace Vulkan::ShaderCompiler
@@ -21,6 +22,9 @@ namespace Vulkan::ShaderCompiler
 static const char SHADER_HEADER[] = R"(
   // Target GLSL 4.5.
   #version 450 core
+
+  #extension GL_ARB_shading_language_include : enable
+
   #define ATTRIBUTE_LOCATION(x) layout(location = x)
   #define FRAGMENT_OUTPUT_LOCATION(x) layout(location = x)
   #define FRAGMENT_OUTPUT_LOCATION_INDEXED(x, y) layout(location = x, index = y)
@@ -121,27 +125,31 @@ static glslang::EShTargetLanguageVersion GetLanguageVersion()
   return glslang::EShTargetSpv_1_0;
 }
 
-std::optional<SPIRVCodeVector> CompileVertexShader(std::string_view source_code)
+std::optional<SPIRVCodeVector> CompileVertexShader(std::string_view source_code,
+                                                   VideoCommon::ShaderIncluder* shader_includer)
 {
   return SPIRV::CompileVertexShader(GetShaderCode(source_code, SHADER_HEADER), APIType::Vulkan,
-                                    GetLanguageVersion());
+                                    GetLanguageVersion(), shader_includer);
 }
 
-std::optional<SPIRVCodeVector> CompileGeometryShader(std::string_view source_code)
+std::optional<SPIRVCodeVector> CompileGeometryShader(std::string_view source_code,
+                                                     VideoCommon::ShaderIncluder* shader_includer)
 {
   return SPIRV::CompileGeometryShader(GetShaderCode(source_code, SHADER_HEADER), APIType::Vulkan,
-                                      GetLanguageVersion());
+                                      GetLanguageVersion(), shader_includer);
 }
 
-std::optional<SPIRVCodeVector> CompileFragmentShader(std::string_view source_code)
+std::optional<SPIRVCodeVector> CompileFragmentShader(std::string_view source_code,
+                                                     VideoCommon::ShaderIncluder* shader_includer)
 {
   return SPIRV::CompileFragmentShader(GetShaderCode(source_code, SHADER_HEADER), APIType::Vulkan,
-                                      GetLanguageVersion());
+                                      GetLanguageVersion(), shader_includer);
 }
 
-std::optional<SPIRVCodeVector> CompileComputeShader(std::string_view source_code)
+std::optional<SPIRVCodeVector> CompileComputeShader(std::string_view source_code,
+                                                    VideoCommon::ShaderIncluder* shader_includer)
 {
   return SPIRV::CompileComputeShader(GetShaderCode(source_code, COMPUTE_SHADER_HEADER),
-                                     APIType::Vulkan, GetLanguageVersion());
+                                     APIType::Vulkan, GetLanguageVersion(), shader_includer);
 }
 }  // namespace Vulkan::ShaderCompiler
diff --git a/Source/Core/VideoBackends/Vulkan/ShaderCompiler.h b/Source/Core/VideoBackends/Vulkan/ShaderCompiler.h
index ff1ea64b979..eab0a04cb5d 100644
--- a/Source/Core/VideoBackends/Vulkan/ShaderCompiler.h
+++ b/Source/Core/VideoBackends/Vulkan/ShaderCompiler.h
@@ -10,6 +10,11 @@
 
 #include "Common/CommonTypes.h"
 
+namespace VideoCommon
+{
+class ShaderIncluder;
+}
+
 namespace Vulkan::ShaderCompiler
 {
 // SPIR-V compiled code type
@@ -17,14 +22,18 @@ using SPIRVCodeType = u32;
 using SPIRVCodeVector = std::vector<SPIRVCodeType>;
 
 // Compile a vertex shader to SPIR-V.
-std::optional<SPIRVCodeVector> CompileVertexShader(std::string_view source_code);
+std::optional<SPIRVCodeVector> CompileVertexShader(std::string_view source_code,
+                                                   VideoCommon::ShaderIncluder* shader_includer);
 
 // Compile a geometry shader to SPIR-V.
-std::optional<SPIRVCodeVector> CompileGeometryShader(std::string_view source_code);
+std::optional<SPIRVCodeVector> CompileGeometryShader(std::string_view source_code,
+                                                     VideoCommon::ShaderIncluder* shader_includer);
 
 // Compile a fragment shader to SPIR-V.
-std::optional<SPIRVCodeVector> CompileFragmentShader(std::string_view source_code);
+std::optional<SPIRVCodeVector> CompileFragmentShader(std::string_view source_code,
+                                                     VideoCommon::ShaderIncluder* shader_includer);
 
 // Compile a compute shader to SPIR-V.
-std::optional<SPIRVCodeVector> CompileComputeShader(std::string_view source_code);
+std::optional<SPIRVCodeVector> CompileComputeShader(std::string_view source_code,
+                                                    VideoCommon::ShaderIncluder* shader_includer);
 }  // namespace Vulkan::ShaderCompiler
diff --git a/Source/Core/VideoBackends/Vulkan/VKGfx.cpp b/Source/Core/VideoBackends/Vulkan/VKGfx.cpp
index a3258a92747..c071d99357a 100644
--- a/Source/Core/VideoBackends/Vulkan/VKGfx.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VKGfx.cpp
@@ -60,9 +60,10 @@ std::unique_ptr<AbstractStagingTexture> VKGfx::CreateStagingTexture(StagingTextu
 }
 
 std::unique_ptr<AbstractShader>
-VKGfx::CreateShaderFromSource(ShaderStage stage, std::string_view source, std::string_view name)
+VKGfx::CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                              VideoCommon::ShaderIncluder* shader_includer, std::string_view name)
 {
-  return VKShader::CreateFromSource(stage, source, name);
+  return VKShader::CreateFromSource(stage, source, shader_includer, name);
 }
 
 std::unique_ptr<AbstractShader> VKGfx::CreateShaderFromBinary(ShaderStage stage, const void* data,
diff --git a/Source/Core/VideoBackends/Vulkan/VKGfx.h b/Source/Core/VideoBackends/Vulkan/VKGfx.h
index 209ea929134..e044bf59ca7 100644
--- a/Source/Core/VideoBackends/Vulkan/VKGfx.h
+++ b/Source/Core/VideoBackends/Vulkan/VKGfx.h
@@ -38,8 +38,10 @@ public:
   CreateFramebuffer(AbstractTexture* color_attachment, AbstractTexture* depth_attachment,
                     std::vector<AbstractTexture*> additional_color_attachments) override;
 
-  std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage, std::string_view source,
-                                                         std::string_view name) override;
+  std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer,
+                         std::string_view name) override;
   std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage, const void* data,
                                                          size_t length,
                                                          std::string_view name) override;
diff --git a/Source/Core/VideoBackends/Vulkan/VKShader.cpp b/Source/Core/VideoBackends/Vulkan/VKShader.cpp
index f0848f1c924..17e13fa7952 100644
--- a/Source/Core/VideoBackends/Vulkan/VKShader.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VKShader.cpp
@@ -108,22 +108,23 @@ CreateShaderObject(ShaderStage stage, ShaderCompiler::SPIRVCodeVector spv, std::
 }
 
 std::unique_ptr<VKShader> VKShader::CreateFromSource(ShaderStage stage, std::string_view source,
+                                                     VideoCommon::ShaderIncluder* shader_includer,
                                                      std::string_view name)
 {
   std::optional<ShaderCompiler::SPIRVCodeVector> spv;
   switch (stage)
   {
   case ShaderStage::Vertex:
-    spv = ShaderCompiler::CompileVertexShader(source);
+    spv = ShaderCompiler::CompileVertexShader(source, shader_includer);
     break;
   case ShaderStage::Geometry:
-    spv = ShaderCompiler::CompileGeometryShader(source);
+    spv = ShaderCompiler::CompileGeometryShader(source, shader_includer);
     break;
   case ShaderStage::Pixel:
-    spv = ShaderCompiler::CompileFragmentShader(source);
+    spv = ShaderCompiler::CompileFragmentShader(source, shader_includer);
     break;
   case ShaderStage::Compute:
-    spv = ShaderCompiler::CompileComputeShader(source);
+    spv = ShaderCompiler::CompileComputeShader(source, shader_includer);
     break;
   default:
     break;
diff --git a/Source/Core/VideoBackends/Vulkan/VKShader.h b/Source/Core/VideoBackends/Vulkan/VKShader.h
index 8414983aaaf..9cf63f94950 100644
--- a/Source/Core/VideoBackends/Vulkan/VKShader.h
+++ b/Source/Core/VideoBackends/Vulkan/VKShader.h
@@ -27,6 +27,7 @@ public:
   BinaryData GetBinary() const override;
 
   static std::unique_ptr<VKShader> CreateFromSource(ShaderStage stage, std::string_view source,
+                                                    VideoCommon::ShaderIncluder* shader_includer,
                                                     std::string_view name);
   static std::unique_ptr<VKShader> CreateFromBinary(ShaderStage stage, const void* data,
                                                     size_t length, std::string_view name);
diff --git a/Source/Core/VideoCommon/AbstractGfx.h b/Source/Core/VideoCommon/AbstractGfx.h
index d739c3f5faa..d9d14e1a120 100644
--- a/Source/Core/VideoCommon/AbstractGfx.h
+++ b/Source/Core/VideoCommon/AbstractGfx.h
@@ -37,7 +37,8 @@ struct SurfaceInfo
 namespace VideoCommon
 {
 class AsyncShaderCompiler;
-}
+class ShaderIncluder;
+}  // namespace VideoCommon
 
 using ClearColor = std::array<float, 4>;
 
@@ -110,9 +111,10 @@ public:
   virtual void PresentBackbuffer() {}
 
   // Shader modules/objects.
-  virtual std::unique_ptr<AbstractShader> CreateShaderFromSource(ShaderStage stage,
-                                                                 std::string_view source,
-                                                                 std::string_view name = "") = 0;
+  virtual std::unique_ptr<AbstractShader>
+  CreateShaderFromSource(ShaderStage stage, std::string_view source,
+                         VideoCommon::ShaderIncluder* shader_includer = nullptr,
+                         std::string_view name = "") = 0;
   virtual std::unique_ptr<AbstractShader> CreateShaderFromBinary(ShaderStage stage,
                                                                  const void* data, size_t length,
                                                                  std::string_view name = "") = 0;
diff --git a/Source/Core/VideoCommon/AbstractShader.h b/Source/Core/VideoCommon/AbstractShader.h
index 3395c44a312..249cc852c16 100644
--- a/Source/Core/VideoCommon/AbstractShader.h
+++ b/Source/Core/VideoCommon/AbstractShader.h
@@ -9,6 +9,14 @@
 
 #include "Common/CommonTypes.h"
 
+// Note: not directly used in this file
+// but done here to avoid specifying in
+// every derived class that needs it
+namespace VideoCommon
+{
+class ShaderIncluder;
+}
+
 enum class ShaderStage
 {
   Vertex,
diff --git a/Source/Core/VideoCommon/CMakeLists.txt b/Source/Core/VideoCommon/CMakeLists.txt
index fb9cba4fa4b..73b9221c4b5 100644
--- a/Source/Core/VideoCommon/CMakeLists.txt
+++ b/Source/Core/VideoCommon/CMakeLists.txt
@@ -147,6 +147,8 @@ add_library(videocommon
   RenderState.h
   ShaderCache.cpp
   ShaderCache.h
+  ShaderCompileUtils.cpp
+  ShaderCompileUtils.h
   ShaderGenCommon.cpp
   ShaderGenCommon.h
   Spirv.cpp
diff --git a/Source/Core/VideoCommon/FramebufferManager.cpp b/Source/Core/VideoCommon/FramebufferManager.cpp
index f3f6d3968ed..9d2382c190c 100644
--- a/Source/Core/VideoCommon/FramebufferManager.cpp
+++ b/Source/Core/VideoCommon/FramebufferManager.cpp
@@ -412,7 +412,7 @@ bool FramebufferManager::CompileConversionPipelines()
     EFBReinterpretType convtype = static_cast<EFBReinterpretType>(i);
     std::unique_ptr<AbstractShader> pixel_shader = g_gfx->CreateShaderFromSource(
         ShaderStage::Pixel,
-        FramebufferShaderGen::GenerateFormatConversionShader(convtype, GetEFBSamples()),
+        FramebufferShaderGen::GenerateFormatConversionShader(convtype, GetEFBSamples()), nullptr,
         fmt::format("Framebuffer conversion pixel shader {}", convtype));
     if (!pixel_shader)
       return false;
@@ -644,7 +644,7 @@ bool FramebufferManager::CompileReadbackPipelines()
   {
     auto depth_resolve_shader = g_gfx->CreateShaderFromSource(
         ShaderStage::Pixel, FramebufferShaderGen::GenerateResolveDepthPixelShader(GetEFBSamples()),
-        "Depth resolve pixel shader");
+        nullptr, "Depth resolve pixel shader");
     if (!depth_resolve_shader)
       return false;
 
@@ -658,7 +658,7 @@ bool FramebufferManager::CompileReadbackPipelines()
       config.framebuffer_state.color_texture_format = GetEFBColorFormat();
       auto color_resolve_shader = g_gfx->CreateShaderFromSource(
           ShaderStage::Pixel,
-          FramebufferShaderGen::GenerateResolveColorPixelShader(GetEFBSamples()),
+          FramebufferShaderGen::GenerateResolveColorPixelShader(GetEFBSamples()), nullptr,
           "Color resolve pixel shader");
       if (!color_resolve_shader)
         return false;
@@ -672,7 +672,7 @@ bool FramebufferManager::CompileReadbackPipelines()
 
   // EFB restore pipeline
   auto restore_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Pixel, FramebufferShaderGen::GenerateEFBRestorePixelShader(),
+      ShaderStage::Pixel, FramebufferShaderGen::GenerateEFBRestorePixelShader(), nullptr,
       "EFB restore pixel shader");
   if (!restore_shader)
     return false;
@@ -888,7 +888,7 @@ void FramebufferManager::ClearEFB(const MathUtil::Rectangle<int>& rc, bool color
 bool FramebufferManager::CompileClearPipelines()
 {
   auto vertex_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Vertex, FramebufferShaderGen::GenerateClearVertexShader(),
+      ShaderStage::Vertex, FramebufferShaderGen::GenerateClearVertexShader(), nullptr,
       "Clear vertex shader");
   if (!vertex_shader)
     return false;
@@ -1063,7 +1063,7 @@ bool FramebufferManager::CompilePokePipelines()
     return false;
 
   auto poke_vertex_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Vertex, FramebufferShaderGen::GenerateEFBPokeVertexShader(),
+      ShaderStage::Vertex, FramebufferShaderGen::GenerateEFBPokeVertexShader(), nullptr,
       "EFB poke vertex shader");
   if (!poke_vertex_shader)
     return false;
diff --git a/Source/Core/VideoCommon/GraphicsModSystem/Runtime/CustomShaderCache.cpp b/Source/Core/VideoCommon/GraphicsModSystem/Runtime/CustomShaderCache.cpp
index 56f8ec1b3b4..a0dca15d382 100644
--- a/Source/Core/VideoCommon/GraphicsModSystem/Runtime/CustomShaderCache.cpp
+++ b/Source/Core/VideoCommon/GraphicsModSystem/Runtime/CustomShaderCache.cpp
@@ -348,7 +348,7 @@ CustomShaderCache::CompilePixelShader(const PixelShaderUid& uid,
 {
   const ShaderCode source_code =
       GeneratePixelShaderCode(m_api_type, m_host_config, uid.GetUidData(), {});
-  return g_gfx->CreateShaderFromSource(ShaderStage::Pixel, source_code.GetBuffer(),
+  return g_gfx->CreateShaderFromSource(ShaderStage::Pixel, source_code.GetBuffer(), nullptr,
                                        "Custom Pixel Shader");
 }
 
@@ -357,7 +357,7 @@ CustomShaderCache::CompilePixelShader(const UberShader::PixelShaderUid& uid,
                                       const CustomShaderInstance& custom_shaders) const
 {
   const ShaderCode source_code = GenPixelShader(m_api_type, m_host_config, uid.GetUidData());
-  return g_gfx->CreateShaderFromSource(ShaderStage::Pixel, source_code.GetBuffer(),
+  return g_gfx->CreateShaderFromSource(ShaderStage::Pixel, source_code.GetBuffer(), nullptr,
                                        "Custom Uber Pixel Shader");
 }
 
diff --git a/Source/Core/VideoCommon/OnScreenUI.cpp b/Source/Core/VideoCommon/OnScreenUI.cpp
index bca12bccddb..8cbd7ca4f04 100644
--- a/Source/Core/VideoCommon/OnScreenUI.cpp
+++ b/Source/Core/VideoCommon/OnScreenUI.cpp
@@ -113,11 +113,11 @@ bool OnScreenUI::RecompileImGuiPipeline()
       g_presenter->GetBackbufferFormat() == AbstractTextureFormat::RGBA16F;
 
   std::unique_ptr<AbstractShader> vertex_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Vertex, FramebufferShaderGen::GenerateImGuiVertexShader(),
+      ShaderStage::Vertex, FramebufferShaderGen::GenerateImGuiVertexShader(), nullptr,
       "ImGui vertex shader");
   std::unique_ptr<AbstractShader> pixel_shader = g_gfx->CreateShaderFromSource(
       ShaderStage::Pixel, FramebufferShaderGen::GenerateImGuiPixelShader(linear_space_output),
-      "ImGui pixel shader");
+      nullptr, "ImGui pixel shader");
   if (!vertex_shader || !pixel_shader)
   {
     PanicAlertFmt("Failed to compile ImGui shaders");
@@ -130,7 +130,7 @@ bool OnScreenUI::RecompileImGuiPipeline()
   {
     geometry_shader = g_gfx->CreateShaderFromSource(
         ShaderStage::Geometry, FramebufferShaderGen::GeneratePassthroughGeometryShader(1, 1),
-        "ImGui passthrough geometry shader");
+        nullptr, "ImGui passthrough geometry shader");
     if (!geometry_shader)
     {
       PanicAlertFmt("Failed to compile ImGui geometry shader");
diff --git a/Source/Core/VideoCommon/PostProcessing.cpp b/Source/Core/VideoCommon/PostProcessing.cpp
index ada1513d1f9..e1cc6e0e60c 100644
--- a/Source/Core/VideoCommon/PostProcessing.cpp
+++ b/Source/Core/VideoCommon/PostProcessing.cpp
@@ -27,6 +27,7 @@
 #include "VideoCommon/FramebufferManager.h"
 #include "VideoCommon/Present.h"
 #include "VideoCommon/ShaderCache.h"
+#include "VideoCommon/ShaderCompileUtils.h"
 #include "VideoCommon/VertexManagerBase.h"
 #include "VideoCommon/VideoCommon.h"
 #include "VideoCommon/VideoConfig.h"
@@ -97,6 +98,9 @@ void PostProcessingConfiguration::LoadShader(const std::string& shader)
   // might have set in the settings
   LoadOptionsConfiguration();
   m_current_shader_code = code;
+  m_shader_includer =
+      std::make_unique<ShaderIncluder>(File::GetUserPath(D_SHADERS_IDX) + sub_dir,
+                                       File::GetSysDirectory() + SHADERS_DIR DIR_SEP + sub_dir);
 }
 
 void PostProcessingConfiguration::LoadDefaultShader()
@@ -809,14 +813,14 @@ bool PostProcessing::CompileVertexShader()
   std::ostringstream ss_default;
   ss_default << GetUniformBufferHeader(false);
   ss_default << GetVertexShaderBody();
-  m_default_vertex_shader = g_gfx->CreateShaderFromSource(ShaderStage::Vertex, ss_default.str(),
-                                                          "Default post-processing vertex shader");
+  m_default_vertex_shader = g_gfx->CreateShaderFromSource(
+      ShaderStage::Vertex, ss_default.str(), nullptr, "Default post-processing vertex shader");
 
   std::ostringstream ss;
   ss << GetUniformBufferHeader(true);
   ss << GetVertexShaderBody();
-  m_vertex_shader =
-      g_gfx->CreateShaderFromSource(ShaderStage::Vertex, ss.str(), "Post-processing vertex shader");
+  m_vertex_shader = g_gfx->CreateShaderFromSource(ShaderStage::Vertex, ss.str(), nullptr,
+                                                  "Post-processing vertex shader");
 
   if (!m_default_vertex_shader || !m_vertex_shader)
   {
@@ -966,7 +970,7 @@ bool PostProcessing::CompilePixelShader()
   if (LoadShaderFromFile(s_default_pixel_shader_name, "", default_pixel_shader_code))
   {
     m_default_pixel_shader = g_gfx->CreateShaderFromSource(
-        ShaderStage::Pixel, GetHeader(false) + default_pixel_shader_code + GetFooter(),
+        ShaderStage::Pixel, GetHeader(false) + default_pixel_shader_code + GetFooter(), nullptr,
         "Default post-processing pixel shader");
     // We continue even if all of this failed, it doesn't matter
     m_default_uniform_staging_buffer.resize(CalculateUniformsSize(false));
@@ -979,6 +983,7 @@ bool PostProcessing::CompilePixelShader()
   m_config.LoadShader(g_ActiveConfig.sPostProcessingShader);
   m_pixel_shader = g_gfx->CreateShaderFromSource(
       ShaderStage::Pixel, GetHeader(true) + m_config.GetShaderCode() + GetFooter(),
+      m_config.GetShaderIncluder(),
       fmt::format("User post-processing pixel shader: {}", m_config.GetShader()));
   if (!m_pixel_shader)
   {
@@ -987,7 +992,7 @@ bool PostProcessing::CompilePixelShader()
     // Use default shader.
     m_config.LoadDefaultShader();
     m_pixel_shader = g_gfx->CreateShaderFromSource(
-        ShaderStage::Pixel, GetHeader(true) + m_config.GetShaderCode() + GetFooter(),
+        ShaderStage::Pixel, GetHeader(true) + m_config.GetShaderCode() + GetFooter(), nullptr,
         "Default user post-processing pixel shader");
     if (!m_pixel_shader)
     {
diff --git a/Source/Core/VideoCommon/PostProcessing.h b/Source/Core/VideoCommon/PostProcessing.h
index b636f3b1332..30a0cac2c27 100644
--- a/Source/Core/VideoCommon/PostProcessing.h
+++ b/Source/Core/VideoCommon/PostProcessing.h
@@ -20,6 +20,8 @@ class AbstractFramebuffer;
 
 namespace VideoCommon
 {
+class ShaderIncluder;
+
 class PostProcessingConfiguration
 {
 public:
@@ -68,6 +70,7 @@ public:
   void SaveOptionsConfiguration();
   const std::string& GetShader() const { return m_current_shader; }
   const std::string& GetShaderCode() const { return m_current_shader_code; }
+  ShaderIncluder* GetShaderIncluder() { return m_shader_includer.get(); }
   bool IsDirty() const { return m_any_options_dirty; }
   void SetDirty(bool dirty) { m_any_options_dirty = dirty; }
   bool HasOptions() const { return m_options.size() > 0; }
@@ -81,6 +84,7 @@ public:
 
 private:
   bool m_any_options_dirty = false;
+  std::unique_ptr<ShaderIncluder> m_shader_includer;
   std::string m_current_shader;
   std::string m_current_shader_code;
   ConfigMap m_options;
diff --git a/Source/Core/VideoCommon/ShaderCache.cpp b/Source/Core/VideoCommon/ShaderCache.cpp
index 74903506905..44868808ddc 100644
--- a/Source/Core/VideoCommon/ShaderCache.cpp
+++ b/Source/Core/VideoCommon/ShaderCache.cpp
@@ -442,7 +442,7 @@ ShaderCache::CompileVertexUberShader(const UberShader::VertexShaderUid& uid) con
 {
   const ShaderCode source_code =
       UberShader::GenVertexShader(m_api_type, m_host_config, uid.GetUidData());
-  return g_gfx->CreateShaderFromSource(ShaderStage::Vertex, source_code.GetBuffer(),
+  return g_gfx->CreateShaderFromSource(ShaderStage::Vertex, source_code.GetBuffer(), nullptr,
                                        fmt::to_string(*uid.GetUidData()));
 }
 
@@ -458,7 +458,7 @@ ShaderCache::CompilePixelUberShader(const UberShader::PixelShaderUid& uid) const
 {
   const ShaderCode source_code =
       UberShader::GenPixelShader(m_api_type, m_host_config, uid.GetUidData());
-  return g_gfx->CreateShaderFromSource(ShaderStage::Pixel, source_code.GetBuffer(),
+  return g_gfx->CreateShaderFromSource(ShaderStage::Pixel, source_code.GetBuffer(), nullptr,
                                        fmt::to_string(*uid.GetUidData()));
 }
 
@@ -555,7 +555,7 @@ const AbstractShader* ShaderCache::CreateGeometryShader(const GeometryShaderUid&
   const ShaderCode source_code =
       GenerateGeometryShaderCode(m_api_type, m_host_config, uid.GetUidData());
   std::unique_ptr<AbstractShader> shader =
-      g_gfx->CreateShaderFromSource(ShaderStage::Geometry, source_code.GetBuffer(),
+      g_gfx->CreateShaderFromSource(ShaderStage::Geometry, source_code.GetBuffer(), nullptr,
                                     fmt::format("Geometry shader: {}", *uid.GetUidData()));
 
   auto& entry = m_gs_cache.shader_map[uid];
@@ -1393,7 +1393,7 @@ ShaderCache::GetEFBCopyToVRAMPipeline(const TextureConversionShaderGen::TCShader
 
   auto shader_code = TextureConversionShaderGen::GeneratePixelShader(m_api_type, uid.GetUidData());
   auto shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Pixel, shader_code.GetBuffer(),
+      ShaderStage::Pixel, shader_code.GetBuffer(), nullptr,
       fmt::format("EFB copy to VRAM pixel shader: {}", *uid.GetUidData()));
   if (!shader)
   {
@@ -1424,8 +1424,9 @@ const AbstractPipeline* ShaderCache::GetEFBCopyToRAMPipeline(const EFBCopyParams
 
   const std::string shader_code =
       TextureConversionShaderTiled::GenerateEncodingShader(uid, m_api_type);
-  const auto shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Pixel, shader_code, fmt::format("EFB copy to RAM pixel shader: {}", uid));
+  const auto shader =
+      g_gfx->CreateShaderFromSource(ShaderStage::Pixel, shader_code, nullptr,
+                                    fmt::format("EFB copy to RAM pixel shader: {}", uid));
   if (!shader)
   {
     m_efb_copy_to_ram_pipelines.emplace(uid, nullptr);
@@ -1447,14 +1448,14 @@ const AbstractPipeline* ShaderCache::GetEFBCopyToRAMPipeline(const EFBCopyParams
 bool ShaderCache::CompileSharedPipelines()
 {
   m_screen_quad_vertex_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Vertex, FramebufferShaderGen::GenerateScreenQuadVertexShader(),
+      ShaderStage::Vertex, FramebufferShaderGen::GenerateScreenQuadVertexShader(), nullptr,
       "Screen quad vertex shader");
   m_texture_copy_vertex_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Vertex, FramebufferShaderGen::GenerateTextureCopyVertexShader(),
+      ShaderStage::Vertex, FramebufferShaderGen::GenerateTextureCopyVertexShader(), nullptr,
       "Texture copy vertex shader");
   m_efb_copy_vertex_shader = g_gfx->CreateShaderFromSource(
       ShaderStage::Vertex, TextureConversionShaderGen::GenerateVertexShader(m_api_type).GetBuffer(),
-      "EFB copy vertex shader");
+      nullptr, "EFB copy vertex shader");
   if (!m_screen_quad_vertex_shader || !m_texture_copy_vertex_shader || !m_efb_copy_vertex_shader)
     return false;
 
@@ -1462,19 +1463,20 @@ bool ShaderCache::CompileSharedPipelines()
   {
     m_texcoord_geometry_shader = g_gfx->CreateShaderFromSource(
         ShaderStage::Geometry, FramebufferShaderGen::GeneratePassthroughGeometryShader(1, 0),
-        "Texcoord passthrough geometry shader");
+        nullptr, "Texcoord passthrough geometry shader");
     m_color_geometry_shader = g_gfx->CreateShaderFromSource(
         ShaderStage::Geometry, FramebufferShaderGen::GeneratePassthroughGeometryShader(0, 1),
-        "Color passthrough geometry shader");
+        nullptr, "Color passthrough geometry shader");
     if (!m_texcoord_geometry_shader || !m_color_geometry_shader)
       return false;
   }
 
   m_texture_copy_pixel_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Pixel, FramebufferShaderGen::GenerateTextureCopyPixelShader(),
+      ShaderStage::Pixel, FramebufferShaderGen::GenerateTextureCopyPixelShader(), nullptr,
       "Texture copy pixel shader");
   m_color_pixel_shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Pixel, FramebufferShaderGen::GenerateColorPixelShader(), "Color pixel shader");
+      ShaderStage::Pixel, FramebufferShaderGen::GenerateColorPixelShader(), nullptr,
+      "Color pixel shader");
   if (!m_texture_copy_pixel_shader || !m_color_pixel_shader)
     return false;
 
@@ -1511,7 +1513,7 @@ bool ShaderCache::CompileSharedPipelines()
       auto shader = g_gfx->CreateShaderFromSource(
           ShaderStage::Pixel,
           TextureConversionShaderTiled::GeneratePaletteConversionShader(format, m_api_type),
-          fmt::format("Palette conversion pixel shader: {}", format));
+          nullptr, fmt::format("Palette conversion pixel shader: {}", format));
       if (!shader)
         return false;
 
@@ -1546,7 +1548,7 @@ const AbstractPipeline* ShaderCache::GetTextureReinterpretPipeline(TextureFormat
     return nullptr;
 
   std::unique_ptr<AbstractShader> shader = g_gfx->CreateShaderFromSource(
-      ShaderStage::Pixel, shader_source,
+      ShaderStage::Pixel, shader_source, nullptr,
       fmt::format("Texture reinterpret pixel shader: {} to {}", from_format, to_format));
   if (!shader)
     return nullptr;
@@ -1586,7 +1588,7 @@ ShaderCache::GetTextureDecodingShader(TextureFormat format,
           fmt::format("Texture decoding compute shader: {}", format);
 
   std::unique_ptr<AbstractShader> shader =
-      g_gfx->CreateShaderFromSource(ShaderStage::Compute, shader_source, name);
+      g_gfx->CreateShaderFromSource(ShaderStage::Compute, shader_source, nullptr, name);
   if (!shader)
     return nullptr;
 
diff --git a/Source/Core/VideoCommon/ShaderCompileUtils.cpp b/Source/Core/VideoCommon/ShaderCompileUtils.cpp
new file mode 100644
index 00000000000..ea17162ce9b
--- /dev/null
+++ b/Source/Core/VideoCommon/ShaderCompileUtils.cpp
@@ -0,0 +1,93 @@
+// Copyright 2025 Dolphin Emulator Project
+// SPDX-License-Identifier: GPL-2.0-or-later
+
+#include "VideoCommon/ShaderCompileUtils.h"
+
+#include <fstream>
+#include <ranges>
+
+#include "Common/FileUtil.h"
+#include "Common/StringUtil.h"
+
+namespace VideoCommon
+{
+ShaderIncluder::ShaderIncluder(const std::string& user_path, const std::string& system_path)
+    : m_root_user_path(user_path), m_root_system_path(system_path)
+{
+}
+
+std::vector<std::string> ShaderIncluder::GetIncludes() const
+{
+  const auto keys = std::views::keys(m_include_results);
+  return {keys.begin(), keys.end()};
+}
+
+ShaderIncluder::IncludeResult*
+ShaderIncluder::includeLocal(const char* header_name, const char* includer_name, std::size_t depth)
+{
+  return ProcessInclude(m_root_user_path, header_name, includer_name, depth);
+}
+
+ShaderIncluder::IncludeResult*
+ShaderIncluder::includeSystem(const char* header_name, const char* includer_name, std::size_t depth)
+{
+  return ProcessInclude(m_root_system_path, header_name, includer_name, depth);
+}
+
+void ShaderIncluder::releaseInclude(IncludeResult* result)
+{
+  m_include_results.erase(result->headerName);
+}
+
+ShaderIncluder::IncludeResult* ShaderIncluder::ProcessInclude(const std::string& root,
+                                                              const char* header_name,
+                                                              const char* includer_name,
+                                                              std::size_t depth)
+{
+  m_dirs.resize(depth);
+  if (depth == 1)
+  {
+    const auto includer_dir = GetDirectory(includer_name);
+    if (includer_dir == ".")
+    {
+      m_dirs.push_back(root);
+    }
+    else
+    {
+      m_dirs.push_back(std::string{includer_dir});
+    }
+  }
+
+  // Search through directories back to front
+  for (auto iter = m_dirs.rbegin(); iter != m_dirs.rend(); iter++)
+  {
+    const std::string full_path = WithUnifiedPathSeparators(*iter + '/' + header_name);
+
+    std::string file_data;
+    if (File::ReadFileToString(full_path, file_data))
+    {
+      m_dirs.push_back(std::string{GetDirectory(full_path)});
+
+      const char* file_bytes = file_data.data();
+      const std::size_t file_size = file_data.size();
+      IncludeResultData result_data{
+          .result = std::make_unique<IncludeResult>(full_path, file_bytes, file_size, nullptr),
+          .file_data = std::move(file_data)};
+
+      auto ptr = result_data.result.get();
+      m_include_results[full_path] = std::move(result_data);
+      return ptr;
+    }
+  }
+  return nullptr;
+}
+
+std::string_view ShaderIncluder::GetDirectory(std::string_view path) const
+{
+  const auto last_pos = path.find_last_of('/');
+  if (last_pos == std::string_view::npos)
+    return ".";
+
+  return path.substr(0, last_pos);
+}
+}  // namespace VideoCommon
diff --git a/Source/Core/VideoCommon/ShaderCompileUtils.h b/Source/Core/VideoCommon/ShaderCompileUtils.h
new file mode 100644
index 00000000000..c3023922483
--- /dev/null
+++ b/Source/Core/VideoCommon/ShaderCompileUtils.h
@@ -0,0 +1,46 @@
+// Copyright 2025 Dolphin Emulator Project
+// SPDX-License-Identifier: GPL-2.0-or-later
+
+#pragma once
+
+#include <map>
+#include <memory>
+#include <string>
+#include <vector>
+
+#include "ShaderLang.h"
+
+namespace VideoCommon
+{
+class ShaderIncluder final : public glslang::TShader::Includer
+{
+public:
+  ShaderIncluder(const std::string& user_path, const std::string& system_path);
+  ~ShaderIncluder() override = default;
+
+  std::vector<std::string> GetIncludes() const;
+
+private:
+  IncludeResult* includeLocal(const char* header_name, const char* includer_name,
+                              std::size_t depth) override;
+  IncludeResult* includeSystem(const char* header_name, const char* includer_name,
+                               std::size_t depth) override;
+  void releaseInclude(IncludeResult* result) override;
+
+  IncludeResult* ProcessInclude(const std::string& root, const char* header_name,
+                                const char* includer_name, std::size_t depth);
+  std::string_view GetDirectory(std::string_view path) const;
+
+  std::string m_root_user_path;
+  std::string m_root_system_path;
+  std::vector<std::string> m_dirs;
+
+  struct IncludeResultData
+  {
+    std::unique_ptr<IncludeResult> result;
+    std::string file_data;
+  };
+  std::map<std::string, IncludeResultData, std::less<>> m_include_results;
+};
+
+}  // namespace VideoCommon
diff --git a/Source/Core/VideoCommon/Spirv.cpp b/Source/Core/VideoCommon/Spirv.cpp
index 59bc872f931..fce9b272bee 100644
--- a/Source/Core/VideoCommon/Spirv.cpp
+++ b/Source/Core/VideoCommon/Spirv.cpp
@@ -159,14 +159,14 @@ const TBuiltInResource* GetCompilerResourceLimits()
 std::optional<SPIRV::CodeVector>
 CompileShaderToSPV(EShLanguage stage, APIType api_type,
                    glslang::EShTargetLanguageVersion language_version, const char* stage_filename,
-                   std::string_view source)
+                   std::string_view source, glslang::TShader::Includer* shader_includer)
 {
   if (!InitializeGlslang())
     return std::nullopt;
 
   std::unique_ptr<glslang::TShader> shader = std::make_unique<glslang::TShader>(stage);
   std::unique_ptr<glslang::TProgram> program;
-  glslang::TShader::ForbidIncluder includer;
+  glslang::TShader::ForbidIncluder forbid_includer;
   EProfile profile = ECoreProfile;
   EShMessages messages = static_cast<EShMessages>(EShMsgDefault | EShMsgSpvRules);
   if (api_type == APIType::Vulkan || api_type == APIType::Metal)
@@ -209,7 +209,7 @@ CompileShaderToSPV(EShLanguage stage, APIType api_type,
   };
 
   if (!shader->parse(GetCompilerResourceLimits(), default_version, profile, false, true, messages,
-                     includer))
+                     shader_includer ? *shader_includer : forbid_includer))
   {
     DumpBadShader("Failed to parse shader");
     return std::nullopt;
@@ -277,26 +277,34 @@ CompileShaderToSPV(EShLanguage stage, APIType api_type,
 namespace SPIRV
 {
 std::optional<CodeVector> CompileVertexShader(std::string_view source_code, APIType api_type,
-                                              glslang::EShTargetLanguageVersion language_version)
+                                              glslang::EShTargetLanguageVersion language_version,
+                                              glslang::TShader::Includer* shader_includer)
 {
-  return CompileShaderToSPV(EShLangVertex, api_type, language_version, "vs", source_code);
+  return CompileShaderToSPV(EShLangVertex, api_type, language_version, "vs", source_code,
+                            shader_includer);
 }
 
 std::optional<CodeVector> CompileGeometryShader(std::string_view source_code, APIType api_type,
-                                                glslang::EShTargetLanguageVersion language_version)
+                                                glslang::EShTargetLanguageVersion language_version,
+                                                glslang::TShader::Includer* shader_includer)
 {
-  return CompileShaderToSPV(EShLangGeometry, api_type, language_version, "gs", source_code);
+  return CompileShaderToSPV(EShLangGeometry, api_type, language_version, "gs", source_code,
+                            shader_includer);
 }
 
 std::optional<CodeVector> CompileFragmentShader(std::string_view source_code, APIType api_type,
-                                                glslang::EShTargetLanguageVersion language_version)
+                                                glslang::EShTargetLanguageVersion language_version,
+                                                glslang::TShader::Includer* shader_includer)
 {
-  return CompileShaderToSPV(EShLangFragment, api_type, language_version, "ps", source_code);
+  return CompileShaderToSPV(EShLangFragment, api_type, language_version, "ps", source_code,
+                            shader_includer);
 }
 
 std::optional<CodeVector> CompileComputeShader(std::string_view source_code, APIType api_type,
-                                               glslang::EShTargetLanguageVersion language_version)
+                                               glslang::EShTargetLanguageVersion language_version,
+                                               glslang::TShader::Includer* shader_includer)
 {
-  return CompileShaderToSPV(EShLangCompute, api_type, language_version, "cs", source_code);
+  return CompileShaderToSPV(EShLangCompute, api_type, language_version, "cs", source_code,
+                            shader_includer);
 }
 }  // namespace SPIRV
diff --git a/Source/Core/VideoCommon/Spirv.h b/Source/Core/VideoCommon/Spirv.h
index 4da7b01c178..8a18d5bcc7f 100644
--- a/Source/Core/VideoCommon/Spirv.h
+++ b/Source/Core/VideoCommon/Spirv.h
@@ -21,17 +21,21 @@ using CodeVector = std::vector<CodeType>;
 
 // Compile a vertex shader to SPIR-V.
 std::optional<CodeVector> CompileVertexShader(std::string_view source_code, APIType api_type,
-                                              glslang::EShTargetLanguageVersion language_version);
+                                              glslang::EShTargetLanguageVersion language_version,
+                                              glslang::TShader::Includer* shader_includer);
 
 // Compile a geometry shader to SPIR-V.
 std::optional<CodeVector> CompileGeometryShader(std::string_view source_code, APIType api_type,
-                                                glslang::EShTargetLanguageVersion language_version);
+                                                glslang::EShTargetLanguageVersion language_version,
+                                                glslang::TShader::Includer* shader_includer);
 
 // Compile a fragment shader to SPIR-V.
 std::optional<CodeVector> CompileFragmentShader(std::string_view source_code, APIType api_type,
-                                                glslang::EShTargetLanguageVersion language_version);
+                                                glslang::EShTargetLanguageVersion language_version,
+                                                glslang::TShader::Includer* shader_includer);
 
 // Compile a compute shader to SPIR-V.
 std::optional<CodeVector> CompileComputeShader(std::string_view source_code, APIType api_type,
-                                               glslang::EShTargetLanguageVersion language_version);
+                                               glslang::EShTargetLanguageVersion language_version,
+                                               glslang::TShader::Includer* shader_includer);
 }  // namespace SPIRV