diff --git a/CMake/FindOProfile.cmake b/CMake/FindOProfile.cmake
deleted file mode 100644
index 7f349307f0d..00000000000
--- a/CMake/FindOProfile.cmake
+++ /dev/null
@@ -1,31 +0,0 @@
-# - Try to find OProfile
-# Once done this will define
-# OPROFILE_FOUND - System has OProfile
-# OPROFILE_INCLUDE_DIRS - The OProfile include directories
-# OPROFILE_LIBRARIES - The libraries needed to use OProfile
-
-find_path(OPROFILE_INCLUDE_DIR opagent.h)
-
-find_library(OPROFILE_LIBRARY opagent
-  PATH_SUFFIXES oprofile
-)
-
-set(OPROFILE_INCLUDE_DIRS ${OPROFILE_INCLUDE_DIR})
-set(OPROFILE_LIBRARIES ${OPROFILE_LIBRARY})
-
-include(FindPackageHandleStandardArgs)
-find_package_handle_standard_args(OProfile DEFAULT_MSG
-  OPROFILE_LIBRARY OPROFILE_INCLUDE_DIR
-)
-
-if (OPROFILE_FOUND)
-  if (NOT TARGET OProfile::OProfile)
-    add_library(OProfile::OProfile UNKNOWN IMPORTED)
-    set_target_properties(OProfile::OProfile PROPERTIES
-      IMPORTED_LOCATION ${OPROFILE_LIBRARIES}
-      INTERFACE_INCLUDE_DIRECTORIES ${OPROFILE_INCLUDE_DIRS}
-    )
-  endif()
-endif()
-
-mark_as_advanced(OPROFILE_INCLUDE_DIR OPROFILE_LIBRARY)
diff --git a/CMakeLists.txt b/CMakeLists.txt
index 2f4572f5f16..77eb170452a 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -119,7 +119,6 @@ option(ENCODE_FRAMEDUMPS "Encode framedumps in AVI format" ON)
 
 option(ENABLE_GPROF "Enable gprof profiling (must be using Debug build)" OFF)
 option(FASTLOG "Enable all logs" OFF)
-option(OPROFILING "Enable profiling" OFF)
 
 # TODO: Add DSPSpy
 option(DSPTOOL "Build dsptool" OFF)
@@ -565,16 +564,6 @@ if(ENCODE_FRAMEDUMPS)
   endif()
 endif()
 
-if(OPROFILING)
-  find_package(OProfile)
-  if(OPROFILE_FOUND)
-    message(STATUS "OProfile found, enabling profiling support")
-    add_definitions(-DUSE_OPROFILE=1)
-  else()
-    message(FATAL_ERROR "OProfile not found. Can't build profiling support.")
-  endif()
-endif()
-
 if(ENABLE_HWDB)
   find_package(LIBUDEV REQUIRED)
   if(LIBUDEV_FOUND)
diff --git a/Source/Core/Common/CMakeLists.txt b/Source/Core/Common/CMakeLists.txt
index a2c4b6eb078..69ab3baf6ad 100644
--- a/Source/Core/Common/CMakeLists.txt
+++ b/Source/Core/Common/CMakeLists.txt
@@ -350,10 +350,6 @@ if(USE_UPNP)
   target_link_libraries(common PRIVATE Miniupnpc::miniupnpc)
 endif()
 
-if(OPROFILE_FOUND)
-  target_link_libraries(common PRIVATE OProfile::OProfile)
-endif()
-
 if(ENABLE_LLVM)
   find_package(LLVM CONFIG)
   if(LLVM_FOUND)
diff --git a/Source/Core/Common/JitRegister.cpp b/Source/Core/Common/JitRegister.cpp
index f05a9e2b4db..8e3211182f2 100644
--- a/Source/Core/Common/JitRegister.cpp
+++ b/Source/Core/Common/JitRegister.cpp
@@ -21,19 +21,11 @@
 #include <unistd.h>
 #endif
 
-#if defined USE_OPROFILE && USE_OPROFILE
-#include <opagent.h>
-#endif
-
 #if defined USE_VTUNE
 #include <jitprofiling.h>
 #pragma comment(lib, "jitprofiling.lib")
 #endif
 
-#if defined USE_OPROFILE && USE_OPROFILE
-static op_agent_t s_agent = nullptr;
-#endif
-
 static File::IOFile s_perf_map_file;
 
 namespace Common::JitRegister
@@ -42,11 +34,6 @@ static bool s_is_enabled = false;
 
 void Init(const std::string& perf_dir)
 {
-#if defined USE_OPROFILE && USE_OPROFILE
-  s_agent = op_open_agent();
-  s_is_enabled = true;
-#endif
-
   if (!perf_dir.empty() || getenv("PERF_BUILDID_DIR"))
   {
     const std::string dir = perf_dir.empty() ? "/tmp" : perf_dir;
@@ -61,11 +48,6 @@ void Init(const std::string& perf_dir)
 
 void Shutdown()
 {
-#if defined USE_OPROFILE && USE_OPROFILE
-  op_close_agent(s_agent);
-  s_agent = nullptr;
-#endif
-
 #ifdef USE_VTUNE
   iJIT_NotifyEvent(iJVM_EVENT_TYPE_SHUTDOWN, nullptr);
 #endif
@@ -83,15 +65,11 @@ bool IsEnabled()
 
 void Register(const void* base_address, u32 code_size, const std::string& symbol_name)
 {
-#if !(defined USE_OPROFILE && USE_OPROFILE) && !defined(USE_VTUNE)
+#ifndef USE_VTUNE
   if (!s_perf_map_file.IsOpen())
     return;
 #endif
 
-#if defined USE_OPROFILE && USE_OPROFILE
-  op_write_native_code(s_agent, symbol_name.c_str(), (u64)base_address, base_address, code_size);
-#endif
-
 #ifdef USE_VTUNE
   iJIT_Method_Load jmethod = {0};
   jmethod.method_id = iJIT_GetNewMethodID();